This study presents a comprehensive investigation into the prognostic significance of CCCRGs in HCC. Notably, our research provides the first mechanistic evidence that CENPI promotes HCC malignant ...

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite promising immunotherapy, response rates remain suboptimal. Tumour-associated ...

Hello! Thank you for making this tool :)! I have two conditions and four Xenium samples (from different patients, total n=8) within each. My understanding from the CellChat documentation is that in ...

Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) was recently shown to be an independent risk factor for immune checkpoint inhibitor (ICI)-associated myocarditis. However, the ...

Official support for free-threaded Python, and free-threaded improvements Python’s free-threaded build promises true parallelism for threads in Python programs by removing the Global Interpreter Lock ...

Cellular aging is a central feature of neurodegenerative diseases, and microglia, the brain’s resident immune cells, are especially susceptible. Alas, whether this reflects intrinsic wear and tear or ...

We integrated single-cell RNA sequencing (scRNA-seq) data from primary tumors and metastatic lesions with bulk tissue transcriptomes and plasma-derived exosomal RNA sequencing (RNA-seq).

Gaining insights into the complex pathways and key cell populations involved in immune dysregulation can aid the development of therapeutic approaches to treat polytrauma, which is associated with ...