Remembering ‘Capital Gazette Five’ after deadly shooting 8 years ago

Gerald Fischman “was a voracious reader.” Rob Hiaasen was a strong mentor. John McNamara loved Bruce Springsteen. Rebecca ...
PNAS

Dissection and integration of bursty transcriptional dynamics for complex systems

The study of dynamic biological phenomena, such as differentiation, immune responses, and cancer—which involve multiple, simultaneously occurring biological processes—using destructively measured ...
ahajournals.org

Designing Medically Tailored Meal Interventions: The Food as Medicine for Families (FAME-F) Factorial Randomized Clinical Trial

Medically tailored meals (MTM) have unanswered implementation questions. Providing MTM for a specific individual, rather than the entire household, could underdose if food is shared, but household MTM ...
GitHub

Rumor Spreading Complex Networks Simulations

ruscs provides tools for simulating how rumors spread. The package implements the Maki-Thompson model with support for quasi-stationary method and control strategies for the simulation.
Frontiers

Auditing cognitive drift in AI-driven recommendation: a responsible AI methods protocol with a health case demonstration

We propose a protocol to detect and track cognitive drift caused by algorithmic curation. We confirm that the protocol is interpretable, sensitive, reproducible, and portable across domains. It is ...
C&EN

REINFORCE-ING Chemical Language Models for Drug Discovery

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Chemical language models, combined with reinforcement learning (RL), have shown ...
JSTOR Daily

A Gillespie Algorithm for Non-Markovian Stochastic Processes

The Gillespie algorithm provides statistically exact methods for simulating stochastic dynamics modeled as interacting sequences of discrete events including systems of biochemical reactions or ...
ahajournals.org

Epigenetic Modulation of Vascular Smooth Muscle Cell Phenotype Switching in Early-Onset Acute Myocardial Infarction

The epigenetic mechanisms underlying early-onset acute myocardial infarction (AMI) remain insufficiently characterized. The present study aims to elucidate the pathophysiology of early-onset AMI by ...
eLife

A differentiable Gillespie algorithm for simulating chemical kinetics, parameter estimation, and designing synthetic biological circuits

This important study introduces a fully differentiable variant of the Gillespie algorithm as an approximate stochastic simulation scheme for complex chemical reaction networks, allowing kinetic ...
The Lancet

A deep learning algorithm to detect anaemia with ECGs: a retrospective, multicentre study

aDepartment of Emergency Medicine, Mediplex Sejong Hospital, Incheon, South Korea bDivision of Cardiology, Cardiovascular Center, Mediplex Sejong Hospital, Incheon, South Korea ...
The Lancet

Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis

aMolecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland bOrganismal and Evolutionary Biology Research ...